TYAML - Yet Another Multicolumn Layout for TYPO3
    05.06.2019

    Shedding light on coatings:

    Real-time monitoring of coating quality at industrial scale


    Optical Coherence Tomography (OCT) is increasingly being used for studies of pharmaceutical film coating. OCT allows fast and non-destructive analysis of the coating thickness and quality via high-resolution cross-sectional images. Information about both the coating thickness and the coating quality can be extracted. Most studies and OCT applications performed to date have been limited to off-line measurements and off-line computations of coating features based on data acquired in-line. This study examines OCT’s applicability to an industrial-scale pan coating process. Automated layer detection, classification and thickness calculation were executed in real time. To evaluate the system’s performance, runs with various tablet size, coating solution concentration and operating parameters were carried out and monitored. Our results indicate that, in addition to correct end-point determination, OCT enables real-time monitoring of the coating processes (thickness, homogeneity and roughness) and can support active process control by supplying information about the coating thickness and quality.

    International Journal of Pharmaceutics 566 (2019), p. 57 - 66

    Authors:

    • Stephan Sacher, Research Center Pharmaceutical Engineering GmbH, Graz, Austria
    • Patrick Wahl, Research Center Pharmaceutical Engineering GmbH, Graz, Austria
    • Michael Weißensteiner, Research Center Pharmaceutical Engineering GmbH, Graz, Austria
    • Matthias Wolfgang, Research Center Pharmaceutical Engineering GmbH, Graz, Austria
    • Yekaterina Pokhilchuk, Research Center Pharmaceutical Engineering GmbH, Graz, Austria
    • Bernd Looser, Glatt Maschinen- und Apparatebau AG, Pratteln, Switzerland
    • Jochen Thies, Glatt Maschinen- und Apparatebau AG, Pratteln, Switzerland
    • Andrea Raffa, Phyllon GmbH, Graz, Austria
    • Johannes G. Khinast, Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria

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